Pathogens and Disease Transmission

BiologyAQAEdexcelGCSEUnit: Infection & Response
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The basics

The Invisible Enemy

The Invisible Enemy

In 1854, London was gripped by a cholera outbreak that killed over 600 people in just ten days. Dr John Snow suspected contaminated water was the cause, but most scientists believed diseases spread through "bad air." By mapping the cases, Snow identified a water pump on Broad Street as the source. When the pump handle was removed, the outbreak ended. This was one of the first times someone proved that invisible microorganisms - pathogens - could cause disease and spread through specific routes.

Today we know that pathogens are all around us, but understanding how they spread and cause disease allows us to protect ourselves effectively.

What is a pathogen?: A microorganism that causes disease in living organisms
Hotspot diagram

Tap any label to zoom into the bacterial structure.

Painted cross-section of a bacterial cell with 7 labelled structures: cell wall, cell membrane, cytoplasm and ribosomes, chromosomal DNA, plasmids, flagellum, capsule.
  1. 1
    Cell wallTough outer casing — not cellulose
  2. 2
    Cell membraneGateway controller — same job as in your cells
  3. 3
    CytoplasmWhere chemistry happens — and where proteins are built
  4. 4
    Chromosomal DNAOne circular chromosome — no nuclear envelope
  5. 5
    PlasmidsBonus DNA rings — often carry antibiotic resistance
  6. 6
    FlagellumPropeller tail — moves the bacterium
  7. 7
    CapsuleOuter slime coat — helps avoid the immune system

Tap any label to zoom into the bacterial structure.

Key terms

Biology glossary

What is a pathogen?
A microorganism that causes disease in living organisms
What is direct transmission?
When pathogens are passed directly from one person to another through physical contact
Exam tip

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Disease Prevention Strategies

Personal Hygiene

  • Hand washing: Soap removes pathogens and breaks down protective membranes
  • Respiratory etiquette: Cover coughs and sneezes to prevent airborne transmission
  • Food safety: Cook food thoroughly, wash fruits and vegetables
  • Personal items: Don't share towels, razors, or other personal items

Medical Interventions

  • Vaccination: Trains immune system to recognize specific pathogens
  • Antibiotics: Kill bacteria but not viruses, fungi, or protists
  • Antifungal medications: Target fungal infections
  • Isolation: Separate infected individuals to prevent spread

Environmental Control

  • Vector control: Eliminate breeding sites (standing water for mosquitoes)
  • Sanitation: Clean water supplies and sewage treatment
  • Food safety systems: Hygiene standards in food preparation
  • Quarantine: Restrict movement of potentially infected individuals

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What is a pathogen?

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