Types of Gene Mutation: Substitution vs Deletion vs Insertion

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⚖️ Types of Gene Mutation: Substitution vs Deletion vs Insertion

Mutation type What happens to DNA Effect on protein Severity
Substitution One base replaced by a different base At most one codon changes → at most one amino acid changes. If degenerate, protein may be unchanged (silent mutation). Variable — can be harmless or serious (e.g. sickle cell)
Deletion One (or more) base removed from the sequence Frameshift: ALL codons after the deletion point are read in the wrong frame → protein completely altered from that point Usually severe — most of the protein sequence is wrong
Insertion One (or more) extra base inserted into the sequence Frameshift: same as deletion — all codons after insertion point are wrong Usually severe — same as deletion

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